ELSEVIER Biochemical plan Journal 2 ( 1998) Biochemical Engineering Journal 1 l-21 A structured seat for penicillin take on mixed substrates G.C. Paul, M.T. Syddall, C.A. Kent, C.R. Thomas * Centre for Bioprocess Engineering, domesticate of chemical Received Engineering, 23 January The University of Birmingham, 1998; accepted 7 May Edgbaston, Birmingham, B15 2lT, UK 1998 abridgment A structured energising modelpreviouslydeveloped describe growth,differentiation, penicillinproduction Penicillium chryysoto the and of genum has been intensify andextended orderto apply it to a mixedcarbonsource fermentation. filamentous in The hyphae dividedinto are four-spot distinctregions thebasis theiractivitiesandthephysiological on of structure (i.e., vacuolation)of thehyphalcompartments: actively viz., growing(mainly apical)regions, non-growing penicillinproducing or regions, vacuoles, degenerated metabolic ally and or inactiveregions. A simpleapproach takento give quantitative is descriptions hyphal extension, of branchformation,vacuolation differentiation.The and fermentation medium contained lucose andlactose g monohydrate the maincarbonsources.
The source the lactose whey powder as of was wage in excess in theinoculum medium, whilstglucose fedcontinuously was throughout fermentation. the Lactose,disaccharide, is hydrolysed a to twain monosaccharides, glucose and gaiactose, when the rest period glucose concentration in the medium drops to a very gloomy level. The utilisationof glucose that of g alactose and following the hydrolysisof la! ctosewereobserved occursimultaneously. allowedthe to This assumption simplelactoseutilisationkineticsin which lactosehydrolysiscould be considered producingan equivalentamountof of as glucose. model been sed for successful The has u predictions fed-batch of penicillinfermentations usinganindustrial chyogenum strain P. under...If you expect to tick a full essay, order it on our website:
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